The lysis of artificially induced intravascular clots in man by intravenous infusions of streptokinase.
نویسندگان
چکیده
منابع مشابه
Studies on the heterogeneity of fibrinolytic activity in artificially induced intravascular clots.
This study was designed to investigate the effectiveness of enhancing local fibrinolytic actvity in intravascular clots preventing side reactions resulting from fibrinolytic activation in the circulating blood. For this purpose, the following procedures were performed. Artificial intravenous clots were induced in femoral and external jugular veins of dogs by three different methods. To dogs at ...
متن کاملLysis of Intravascular Blood
The purposes of the present s tudy have been to explore the possibility of producing a strongly active fibrinolytic system in the circulating blood of rabbits by intravenous injections of streptokinase and to observe its effect on art ificially induced intravascular clots. In developing the study, a number of quantitative estimations have been made pertaining to the streptococcal fibrinolytic s...
متن کاملThe Lysis in Rabbits of Intravascular Blood Clots by the Streptococcal Fibrinolytic System (streptokinase)
1. Based upon quantitative estimations of the factors that promote or retard the development and activity of the streptococcal fibrinolytic phenomenon, an active lytic system was developed within the circulating blood stream of rabbits following the intravenous infusion of streptokinase. During the infusion of adequate doses of SK, an active lytic system was observed to be present within 30 min...
متن کاملComparative immunogenicity and thrombolytic properties toward arterial and venous thrombi of streptokinase and recombinant staphylokinase in baboons.
BACKGROUND Streptokinase is a routinely used thrombolytic agent that is immunogenic and relatively inefficient toward platelet-rich thrombus, whereas staphylokinase is a poorly studied fibrinolytic agent. Here, the comparative immunogenicity and thrombolytic properties toward arterial platelet-rich thrombus and venous whole blood clots of streptokinase and recombinant staphylokinase were studie...
متن کاملBiological Activity Analysis of Native and Recombinant Streptokinase Using Clot Lysis and Chromogenic Substrate Assay
Determination of streptokinase activity is usually accomplished through two assay methods: a) Clot lysis, b) Chromogenic substrate assay. In this study the biological activity of two streptokinase products, namely Streptase®, which is a native product and Heberkinasa®, which is a recombinant product, was determined against the third international reference standard using the two forementioned a...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 38 شماره
صفحات -
تاریخ انتشار 1959